Director Curtis Hanson approached Toni Collette before filming and asked the actress about gaining weight for the part. Collette had complied and proceeded to gain 25 pounds for the part, which she subsequently lost during the film's shooting which is to reflect her character.
Both the sister and the grandmother of the author of the original book (Jennifer Weiner) appear in the movie.
Jennifer Weiner (the author) and her agent appear walking behind Toni Collette and her friend "Amy" in the Italian Market scene.
The woman pictured as Maggie and Rose's mother is model Ivana Milicevic
The poem Maggie reads in the wedding scene is e.e. cummings's "I Carry Your Heart".
The poem that Maggie reads to the bedridden professor is ‘One Art’ by Elizabeth Bishop.
The second poem Maggie reads is by Jane Kenyon – ‘Let Evening Come’.
Althought Cameron Diaz plays 'Toni Collete''s younger sister, Diaz is 2 months older than Collete in real life.
An animated open title sequence was created for the film a year before its release and then cut from the final picture when the producers decided to make the film seem more serious.