Ben Stiller mentioned while on a talk show promoting the film that the ferret bit him a couple of times during production, including one time latching onto his chin.
The green flag on Leyland Van Lew's yacht features the 'boxing kangaroo' which was flown from Australia II during the 1983 America's Cup campaign in which Australia was successful.
Reuben (Ben Stiller) writes a list to compare Polly (Jennifer Aniston) against Lisa (Debra Messing). This is found by Polly and leads to an argument. This is similar to Season 2 of "Friends" (1994) when Rachel (Aniston) is compared to Ross's (David Schwimmer) current girlfriend.
The building Leland van Lew jumps off of in Los Angeles is the AT&T Tower (611 W. 6th Street), designed by William L. Pereira in 1969 as the city's tallest skyscraper.
Jennifer Aniston (Polly) and Debra Messing (Lisa) both starred on very successful, and some might say, rival, sitcoms, "Friends" (1994) and "Will & Grace" (1998). However, they also have numerous connections with other co-stars of Along Came Polly (2004), through the two shows. Ben Stiller (Reuben) appeared on 'Friends', in 1994, as Tommy, Rachel's (Aniston) date, in 'The One With The Screamer'. In addition, Stiller's wife, 'Christine Taylor', also made a guest appearance as Bonnie, Ross's girlfriend, in 1997. Moreover, Hank Azaria (Claude) appeared on 'Friends' as a regular guest, as Phoebe's on/off boyfriend, David. Messing starred alongside Dermot Mulroney in The Wedding Date (2005) who also made a guest appearance in 'Friends', as Gavin, in 2003, as Rachel's (Aniston) work colleague. Finally, Alec Baldwin (Stan) appeared alongside Messing in Will & Grace, in 2005, as Malcolm, and also in 'Friends' as Parker, Phoebe's overly positive annoying boyfriend.
According to an interview, Jennifer Aniston stated that the reasons she worked on this film was both to work with her friend Ben Stiller and to dance the salsa.