- The movie is set before the events of the first House of the Dead video game.
- Thirty-two video clips from the original game appear in several parts of the movie. Twenty-six appear during the 10-minute battle in front of the house. The remaining 6 are used as transitions prior to the battle.
- The fisherman with the hook (gaff) at the beginning of the movie is a reference to the killer in I Know What You Did Last Summer (1997).
- At the beginning of the movie, Greg says, "Who's the U-boat captain?" when he sees Capt. Viktor Kirk (Jürgen Prochnow). Prochnow was the captain in Das Boot (1981)
- The Sega logo is in the background during the rave. Sega produced the "House of the Dead" video game.
- Jonathan Cherry burned 30% of his hand on the second day of shooting. The scene on the bridge, where he hurts his hand, was shot later, to explain the bandage he had to wear.
- Reviews were so bad that Danish cinemas refused to buy it.
- House of the Dead is the last film to use the turn-table technique for 360° shots. The risk of actors being hurt or killed by the fast-moving camera was too much.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: At the end, the survivors are rescued by a helicopter. Two men in trench coats get of the helicopter as it lands. This is a reference to the original House of the Dead video game, in which the protagonists are two special agents in trench coats.
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