Alanna Ubach, who plays Greg Focker's former nanny, Isabelle, is actually 10 years younger than Ben Stiller.
The horn on the Byrnes' RV plays the tune of "Puff the Magic Dragon", about which Greg and Jack had a conversation in Meet the Parents (2000).
During production, the proposed title of "Meet the Fockers" was thought by the studio to be too vulgar. The spelling was briefly changed to "Meet the Fokkers", but that would have upset the franchise's continuity, so it was changed back.
The flight attendant is Kali Rocha the same actress from Meet the Parents (2000). That's why Greg gives her an odd look when she offers to take his bag and be helpful.
The MPAA would not allow the movie to use the title unless they found a family with the name "Focker".
The rum bottle that the Fockers have in their house is Mount Gay Rum.
James Brolin was originally approached for the role of Bernie but turned it down. When director Jay Roach went to approach Dustin Hoffman for the role, Hoffman was talking non-stop and even out of the point which made him the instant choice for Bernie.
When visiting the Focker household, Pam is seen looking at a vinyl record. The album is "Make It Big", released by Wham! in 1984.
The close-up of Bernie Focker's license plate, as he and Greg are driving away, reveals the letters TMI, a subtle reference to Bernie's propensity for overly detailed explanations and descriptions of personal information. TMI is the literary abbreviation for Too Much Information.