One scene called for actor Al Pacino to be surprised after opening a door. Star Trek VI: The Undiscovered Country (1991) was filming in a nearby studio, so director Garry Marshall arranged for Kirk and Spock be on the other side of the door that Pacino opened.
The football team on the poster behind Nick when Johnny enters the restaurant for the first time is PAOK from Thessaloniki, Greece, with a double-headed eagle as its emblem.
'Kathy Bates'(I) originated the role of Frankie on the stage. She campaigned to get the role in the film, but lost out to Michelle Pfeiffer.
Playwright Terrence McNallyoriginally wrote the role of Frankie for 'Kathy Bates'(I) . Johnny was played by Kenneth Welsh in the 1987 Off-Broadway production of "Frankie and Johnny in the Clair de Lune" that starred Bates.
In a scene at the beginning, Frankie is on a bus reading a magazine. On the front cover is Penny Marshall, the sister of director Garry Marshall.
Frankie agrees to open her robe for 15 seconds so that Johnny can look at her nude. She actually does it for over 40 seconds.