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In one scene John Candy's Character says that Steves Martin's character plays with his balls.A couple vigorously makes outSome pin-up girls are seen in a taxicab
Neal is punched out by an airport attendant. Then the airport attendant picks him up by his crotch.
The f-word is used 19 times during one sceneOther milder profanities are used
John Candy's Character smokes cigarettes during a lot of the scenes in the film. Neal and Dell also get drunk together in their final motel room.
There is a scene where Steve Martin and John Candy are driving the wrong way down a freeway and they are forced in between two juggernauts, flashes of their skeletons (comedic really) and with John Candy laughing maniacally as Satan may frighten some people.