
| Nell Carter | ... | Nellie Ruth 'Nell' Harper (137 episodes, 1981-1987) |
 | Lara Jill Miller | ... | Samantha 'Sam' Kanisky (107 episodes, 1981-1987) |

| Lauri Hendler | ... | Julie Kanisky / ... (97 episodes, 1981-1986) |
 | Kari Michaelson | ... | Katie Kanisky (96 episodes, 1981-1986) |
 | Dolph Sweet | ... | Chief Carl Kanisky (83 episodes, 1981-1985) |
 | John Hoyt | ... | Grandpa Stanley Kanisky (78 episodes, 1982-1987) |

| Joseph Lawrence | ... | Joey Donovan (77 episodes, 1983-1987) |
 | Telma Hopkins | ... | Addy Wilson (68 episodes, 1983-1987) |
 | Howard Morton | ... | Officer Ralph Simpson (50 episodes, 1981-1986) |

| Matthew Lawrence | ... | Matthew Donovan (18 episodes, 1986-1987) |

| Jonathan Silverman | ... | Jonathan Maxwell (16 episodes, 1984-1986) |
 | Rosetta LeNoire | ... | Maybelle 'Mama' Harper (16 episodes, 1985-1987) |

| Rosie O'Donnell | ... | Maggie O'Brien (11 episodes, 1986-1987) |
 | Paul Sand | ... | Marty (10 episodes, 1986-1987) |
 | Peter Schrum | ... | Uncle Ed Kanisky (9 episodes, 1982-1983) |

| Harrison Page | ... | Hamilton Storm / ... (8 episodes, 1981-1984) |
 | Jane Dulo | ... | Grandma Mildred Kanisky (8 episodes, 1982-1983) |
 | Alvernette Jimenez | ... | Angie (6 episodes, 1981-1985) |
 | Don Sherman | ... | Cab Driver / ... (6 episodes, 1982-1986) |
 | Michael J. Henderson | ... | Art (6 episodes, 1984-1985) |
 | Robin Bach | ... | Cameraman / ... (5 episodes, 1982-1983) |
 | Jack Fletcher | ... | Mr. Swackhammer (5 episodes, 1982-1983) |
 | Victoria Carroll | ... | Applicant #1 / ... (4 episodes, 1982-1983) |
 | Rick Fitts | ... | Andrew / ... (4 episodes, 1983-1986) |

| James A. Watson Jr. | ... | James Roland / ... (3 episodes, 1983-1984) |
 | Jay Johnson | ... | Priest / ... (3 episodes, 1981-1982) |
 | Hazel Shermet | ... | Mrs. Larry Rhine / ... (3 episodes, 1981-1982) |
 | Bonnie Urseth | ... | Doris / ... (3 episodes, 1982-1983) |
 | Nat Bernstein | ... | Murphy / ... (3 episodes, 1984-1986) |
 | Phil Leeds | ... | Mr. Galotta / ... (3 episodes, 1984-1985) |
 | Cliff Norton | ... | Mr. Bickford / ... (3 episodes, 1984-1985) |
 | Don Bovingloh | ... | Desk Clerk (3 episodes, 1984) |
 | Lynne Thigpen | ... | Loretta Harper / ... (3 episodes, 1985-1986) |
 | Patrick Collins | ... | Tim Donovan (3 episodes, 1986) |
 | Judy Walton | ... | Receptionist (2 episodes, 1984-1985) |
 | Rue McClanahan | ... | Katrina / ... (2 episodes, 1981-1984) |
 | Nora Boland | ... | Edna / ... (2 episodes, 1981-1982) |
 | Will Hunt | ... | Bill Larkin / ... (2 episodes, 1981-1982) |
 | George Memmoli | ... | New Member / ... (2 episodes, 1981-1982) |
 | Lewis Arquette | ... | Coach Henderson / ... (2 episodes, 1982-1987) |

| Frank Bonner | ... | Officer Baxter / ... (2 episodes, 1982-1985) |

| Basil Hoffman | ... | Mr. Fuller (2 episodes, 1982-1984) |
 | Arlene Golonka | ... | Maxine (2 episodes, 1982-1983) |
 | Hilda Haynes | ... | Mrs. Harper / ... (2 episodes, 1982-1983) |
 | Jack Carter | ... | Customer / ... (2 episodes, 1982) |
 | Phil Rubenstein | ... | Captain Luchesi / ... (2 episodes, 1982) |

| John Otrin | ... | Police Officer / ... (2 episodes, 1983-1985) |
 | Patricia Veselich | ... | Karen / ... (2 episodes, 1983-1985) |
 | Roslyn Kind | ... | Female Student / ... (2 episodes, 1983-1984) |

| Liz Torres | ... | Nurse #2 / ... (2 episodes, 1983-1984) |
 | Maggie Cooper | ... | Mary Beth Sinclair (2 episodes, 1983) |
 | Jack Lindine | ... | The Mad Bomber (2 episodes, 1983) |

| Allan Rich | ... | Judge (2 episodes, 1983) |
 | Teddy Wilson | ... | Club Owner / ... (2 episodes, 1984-1987) |

| Michael Dorn | ... | Major Carpenter / ... (2 episodes, 1984-1986) |
 | Leonard Lightfoot | ... | Dr. Jamel Anderson / ... (2 episodes, 1984-1985) |
 | Nedra Volz | ... | Maid (2 episodes, 1984-1985) |
 | Ric Mancini | | (2 episodes, 1984) |
 | Pam Matteson | ... | Nurse #1 / ... (2 episodes, 1984) |

| Raf Mauro | | (2 episodes, 1984) |
 | Fred McCarren | ... | Tim Donovan (2 episodes, 1984) |
 | Charles Weldon | ... | Charlie Johnson (2 episodes, 1984) |
 | Kurt McKinney | ... | Chip / ... (2 episodes, 1985-1986) |
 | Arnold F. Turner | ... | Fireman / ... (2 episodes, 1985-1986) |
 | Hakeem Abdul-Samad | ... | Jerome (2 episodes, 1985) |

| Gerald Berns | ... | Carwash Guy / ... (2 episodes, 1985) |
 | René Le Vant | ... | Howard (2 episodes, 1985) |

| Marie-Alise Recasner | ... | Tammy (2 episodes, 1985) |
 | Count Stovall | ... | Tony (2 episodes, 1985) |

| Mark L. Taylor | ... | Mr. Broderick (2 episodes, 1986-1987) |

| Gary Collins | ... | Himself (2 episodes, 1986) |
 | Patrick Breen | ... | Keith Dudley (2 episodes, 1987) |
 | Blake Clark | ... | B.J. O'Brien (2 episodes, 1987) |

| Todd Field | ... | Eric (2 episodes, 1987) |
 | Joseph Maher | ... | Professor Dudley (2 episodes, 1987) |

| Susan Marie Snyder | ... | Linda (2 episodes, 1987) |
 | Charles Zucker | | (2 episodes, 1987) |
|
| Franco Bario | .... | production assistant / production coordinator (48 episodes, 1985-1987) |
| Michael Mount | .... | production executive (31 episodes, 1982-1983) |
| Rod Parker | .... | script supervisor / executive story supervisor / ... (6 episodes, 1983-1986) |
| Tom Biener | .... | executive script consultant / executive story consultant (5 episodes, 1983-1985) |
| Ron Landry | .... | executive script consultant / executive story consultant (5 episodes, 1983-1985) |
| Gary H. Miller | .... | executive story editor / story editor (5 episodes, 1983-1985) |
| Lorraine Sevre-Richmond | .... | production associate (4 episodes, 1983-1985) |
| Arthur Julian | .... | executive story supervisor / executive script supervisor / ... (4 episodes, 1984-1986) |
| Gus Hornsby | .... | story editor (4 episodes, 1984-1985) |
| Tom Milo | .... | stage manager / assistant to producers (3 episodes, 1984-1986) |
| Gwen McCracken | .... | assistant to producers (3 episodes, 1984-1985) |
| Jeff Meyer | .... | stage manager (2 episodes, 1983-1984) |
| Len Uslaner | .... | technical director (2 episodes, 1983-1984) |
| Franklin Jones | .... | assistant to producers (2 episodes, 1985) |
| Bill Koshoway | .... | assistant to producers (2 episodes, 1985) |
| Kate McCallum | .... | assistant to producers (2 episodes, 1985) |
| Jeffrey M. Meyer | .... | stage manager (2 episodes, 1985) |
| Wendy Murphey | .... | assistant to producers (2 episodes, 1985) |
| Meredith Siler | .... | assistant to producers (2 episodes, 1985) |
| Adam Waynert | .... | assistant to producers (2 episodes, 1985) |
|
| Dick Woodka | .... | technical director (unknown episodes) |
| |