Helen Eileen Beardsley (who wrote the book Who Gets the Drumsticks? on which this was based) died 26 April 2000, aged 70, Healdsburg, California, USA (Parkinson's disease).
The wedding invitation used in the movie is the actual wedding invitation designed by Frank Beardsley, husband of the real Helen Eileen Beardsley. The children's names are listed in their real-life birth order.
The baby born at the end of the movie is Joseph John Beardsley. He was born in the early hours of 14 July 1962.
Lucille Ball co-produced the film under her company, Desilu Productions. When the film became a surprise smash hit grossing over $17 million on a $2.5 million investment, she became furious about it. She hadn't anticipated the film's huge box-office success and failed to provide a tax shelter for her personal profits, resulting in most of her share going in taxes.
Henry Fonda replaced Fred MacMurray on short notice.
The commercial success of Yours, Mine and Ours led ABC and Paramount Studios to green-light "The Brady Bunch" (1969).
When the television show, "The Brady Bunch" (1969) was in the beginning phases of production, the makers of "Yours, Mine and Ours" threatened to sue claiming that the concept was too similar to there own. The threat was withdrawn, however, when Brady Bunch producer Sherwood Schwartz countered their action with documentation that his original script was shown to have a copy written date before that of the movies. The final evidence that halted any legal proceedings before it fully commenced was the fact the the Brady Bunche's original title, according to the original draft of Schwartz's script, was "Yours and Mine."