Anything's possible, but, if one is to believe the accounts of both Gable and Monroe, the answer is no. Both on and off the set, they expressed genuine admiration, respect, and affection for one another. It is true that Marilyn Monroe was dealing with very difficult personal issues during the making of this film and was often under the influence of drugs and alcohol during the production. By several accounts, she was often late to the set, and sometimes didn't show up at all. But the hot Nevada desert was a difficult film location in many respects; most of the principal actors and many of the crew, not just Gable and Monroe, felt very tired and worn out both during and immediately after the film's production. And Monroe wasn't the only star causing problems and production delays during shooting. Montgomery Clift was also battling drug and alcohol abuse during the production, often causing Gable to lose his patience (and his temper).
After Gable died, a reporter quoted a comment from Kay Gable, Clark Gable's wife, that she felt that the "eternal waiting" on the set of "The Misfits" had contributed to her husband's death, but she didn't specifically mention Marilyn Monroe and, as stated earlier, shooting a film in the desert is almost always an arduous task at best and production delays in such conditions are generally the rule and not the exception, even when the principal actors are consistently sober and focused every day (which clearly Monroe and Clift were not). In any event, when Marilyn Monroe did cause production delays, it was probably a more positive than negative thing for Gable, as his contract for "The Misfits" guaranteed him a staggering $48,000 a week in overtime pay, so the longer he was there, the more money he made. Also, to blame Gable's heart attack entirely on stress caused by Monroe is unfair, as Gable's lifelong history of crash dieting, hard drinking, and heavy smoking (three packs of cigarettes and a dozen cigars per day by some accounts) indoubtably played a part in his untimely demise from heart failure just days after filming was completed. In addition, as mentioned elsewhere in this FAQ, Gable was an outdoors type, a "man's man", and insisted on doing many of his own stunts during the production; this would have put a great physical strain on anyone, especially a 59 year old man who was not in peak physical condition at the time.