 | Allan Lane | ... | Mister Ed (126 episodes, 1958-1966) |
 | Alan Young | ... | Wilbur Post (125 episodes, 1961-1966) |
 | Connie Hines | ... | Carol Post (125 episodes, 1961-1966) |
 | Larry Keating | ... | Roger Addison (70 episodes, 1961-1963) |
 | Edna Skinner | ... | Kay Addison (69 episodes, 1961-1964) |
 | Leon Ames | ... | Gordon Kirkwood (40 episodes, 1963-1966) |
 | Florence MacMichael | ... | Winnie Kirkwood (39 episodes, 1963-1966) |
 | Barry Kelley | ... | Carol's Father / ... (11 episodes, 1962-1966) |
 | James Flavin | ... | Kramer, the Blacksmith / ... (8 episodes, 1961-1965) |
 | Richard Deacon | ... | Dr. Stekel, the Shrink / ... (7 episodes, 1961-1964) |
 | Joe Conley | ... | Photographer / ... (6 episodes, 1961-1965) |
 | Jack Albertson | ... | Paul Fenton (6 episodes, 1961-1964) |
 | Mister Ed | ... | Himself (5 episodes, 1958-1964) |
 | Barbara Morrison | ... | Customer / ... (5 episodes, 1961-1965) |
 | Logan Field | ... | Hogan / ... (4 episodes, 1961-1965) |
 | Richard Reeves | ... | Charlie, Union Truck Terminal Worker / ... (4 episodes, 1961-1965) |
 | Hazel Shermet | ... | Lady in Shower / ... (4 episodes, 1961-1965) |
 | Ben Welden | ... | Joe, Union Truck Terminal Worker / ... (4 episodes, 1961-1965) |
 | Frank Wilcox | ... | Dr. Chadkin / ... (4 episodes, 1961-1965) |
 | Ray Kellogg | ... | Frank / ... (4 episodes, 1962-1966) |
 | Karl Lukas | ... | Charlie / ... (4 episodes, 1962-1965) |
 | Nick Stewart | ... | Mailman / ... (4 episodes, 1964-1965) |
 | John Qualen | ... | Axel the Handyman / ... (3 episodes, 1961-1965) |

| Donna Douglas | ... | Blanche Dickenson / ... (3 episodes, 1961-1962) |
 | Mary Carroll | ... | Mrs. Harkness / ... (3 episodes, 1958-1964) |
 | Henry Corden | ... | Mordini the Magician / ... (3 episodes, 1961-1965) |
 | Rolfe Sedan | ... | Dr. Robbins / ... (3 episodes, 1961-1965) |

| Howard Wendell | ... | Mr. Reeves / ... (3 episodes, 1961-1965) |
 | Jay Ose | ... | Joe Haskell / ... (3 episodes, 1961-1964) |
 | Olan Soule | ... | Mr. Goodwin / ... (3 episodes, 1961-1964) |
 | Al Checco | ... | Joe King (3 episodes, 1961-1963) |
 | Lisabeth Field | ... | Bank Teller / ... (3 episodes, 1962-1965) |
 | Neil Hamilton | ... | Harvey Aynsworth / ... (3 episodes, 1962-1965) |
 | Hugh Sanders | ... | Detective Hawkins / ... (3 episodes, 1962-1965) |
 | Chick Chandler | ... | Bill Hodges / ... (3 episodes, 1962-1964) |

| Norman Leavitt | ... | Holly / ... (3 episodes, 1962-1964) |
 | Robert Carson | ... | Benson / ... (3 episodes, 1962-1963) |
 | Lee Goodman | ... | Cub Scout Leader / ... (3 episodes, 1962-1963) |
 | George N. Neise | ... | Dr. Jay Pearson / ... (3 episodes, 1964-1965) |
 | George O'Hanlon | ... | George Harper / ... (2 episodes, 1962-1964) |
 | Coleen Gray | ... | Annie Parker / ... (2 episodes, 1961-1962) |
 | Ray Walker | ... | Cameraman (2 episodes, 1958-1962) |
 | Peter Leeds | ... | Hal Robbins / ... (2 episodes, 1961-1964) |
 | Peter Brooks | ... | Andy / ... (2 episodes, 1962-1964) |
 | Elvia Allman | ... | Ida Brenner / ... (2 episodes, 1961) |
 | Eleanor Audley | ... | Aunt Martha (2 episodes, 1961-1965) |
 | George Barrows | ... | Brannigan / ... (2 episodes, 1961-1965) |
 | Les Tremayne | ... | Dr. Brink / ... (2 episodes, 1961-1965) |
 | John Hale | ... | Harold Johnson (2 episodes, 1961-1963) |
 | Jack LaLanne | ... | Himself / ... (2 episodes, 1961-1963) |
 | Karen Norris | ... | Mother / ... (2 episodes, 1961-1963) |
 | Doris Packer | ... | Emma Hoblock / ... (2 episodes, 1961-1963) |

| Anthony Warde | ... | Policeman / ... (2 episodes, 1961-1963) |
 | Don Brodie | ... | Henry Gibson / ... (2 episodes, 1961-1962) |
 | Carole Evern | ... | Secretary / ... (2 episodes, 1961-1962) |
 | Henry Norell | ... | Farmer Dowd / ... (2 episodes, 1961-1962) |
 | Chris Hughes | ... | Newsboy / ... (2 episodes, 1961) |
 | Raymond Bailey | ... | Howard Dieterle / ... (2 episodes, 1962-1965) |
 | Percy Helton | ... | Doc Evans / ... (2 episodes, 1962-1965) |
 | Robert Anderson | ... | Policeman / ... (2 episodes, 1962-1963) |
 | Riza Royce | ... | 1st Party Guest / ... (2 episodes, 1962-1963) |
 | Willard Waterman | ... | Mr. Douglas / ... (2 episodes, 1962-1963) |
 | Ricky Star | ... | Chuck Miller / ... (2 episodes, 1962) |
 | Gail De Cossi | ... | Aerialist / ... (2 episodes, 1963-1965) |
 | Robert Patten | ... | Mr. Page / ... (2 episodes, 1963-1965) |
 | Ginny Tyler | ... | Claudia / ... (2 episodes, 1963-1965) |

| Butch Patrick | ... | Stevie / ... (2 episodes, 1963-1964) |
 | Moyna MacGill | ... | Mrs. Prell / ... (2 episodes, 1963) |

| Sharon Tate | ... | Sailor's Girl / ... (2 episodes, 1963) |
 | Bill Baldwin | ... | Emcee / ... (2 episodes, 1964-1965) |
 | Irwin Charone | ... | Capt. Vernon, Military Psychiatrist / ... (2 episodes, 1964-1965) |
 | June Whitley Taylor | ... | Mimi Hilliard / ... (2 episodes, 1964-1965) |
 | Oscar Beregi Jr. | ... | Kosh (2 episodes, 1965) |
 | Henry Brandon | ... | Derek (2 episodes, 1965) |

| Nobu McCarthy | ... | Mei Ling (2 episodes, 1965) |
 | Robert Nunn | ... | Steve / ... (2 episodes, 1965) |
 | Michael Ross | ... | James / ... (2 episodes, 1965) |