| Dick Van Dyke | ... | Robert 'Rob' Petrie (158 episodes, 1961-1966) |
| Mary Tyler Moore | ... | Laura Petrie (153 episodes, 1961-1966) |
 | Rose Marie | ... | Sally Rogers (131 episodes, 1961-1966) |
| Morey Amsterdam | ... | Maurice B. 'Buddy' Sorrell (131 episodes, 1961-1966) |
| Richard Deacon | ... | Melvin 'Mel' Cooley (108 episodes, 1961-1966) |
| Larry Mathews | ... | Richard Rosebud 'Ritchie' Petrie (70 episodes, 1961-1966) |
| Ann Morgan Guilbert | ... | Millie Helper (61 episodes, 1961-1966) |
| Frank Adamo | ... | Waiter / ... (44 episodes, 1961-1966) |
| Jerry Paris | ... | Jerry Helper / ... (37 episodes, 1961-1966) |
| Carl Reiner | ... | Alan Brady / ... (29 episodes, 1961-1966) |
| Johnny Silver | ... | Waiter / ... (15 episodes, 1963-1965) |
| Allan Melvin | ... | Guard Jenkins / ... (8 episodes, 1961-1966) |
| Tiny Brauer | ... | Cabbie / ... (7 episodes, 1962-1966) |
| Howard Wendell | ... | Dr. Lemler / ... (7 episodes, 1962-1966) |
| Amzie Strickland | ... | Aunt Mildred / ... (7 episodes, 1963-1965) |
| Isabel Randolph | ... | Clara Petrie / ... (6 episodes, 1962-1966) |
| Herbie Faye | ... | Willie / ... (6 episodes, 1962-1965) |
| Ray Kellogg | ... | Captain / ... (6 episodes, 1962-1965) |
| Jerry Hausner | ... | Delivery Man / ... (5 episodes, 1962-1963) |
| Sandy Kenyon | ... | Allergist / ... (5 episodes, 1962-1965) |
| Bill Idelson | ... | Herman Glimscher / ... (5 episodes, 1963-1966) |
| Jane Dulo | ... | Cousin Margaret / ... (4 episodes, 1962-1965) |
| Eleanor Audley | ... | Mrs. Billings / ... (4 episodes, 1961-1963) |
| Jamie Farr | ... | Delivery Boy (4 episodes, 1961) |
| Dabbs Greer | ... | Brumley / ... (4 episodes, 1962-1965) |
| Jerry Van Dyke | ... | Stacey Petrie (4 episodes, 1962-1965) |
| Arthur Batanides | ... | Arnold / ... (4 episodes, 1963-1964) |
| Doris Singleton | ... | Doris Darwell / ... (3 episodes, 1962-1965) |
| Geraldine Wall | ... | Mrs. Meehan / ... (3 episodes, 1962-1964) |
| Lennie Weinrib | ... | Danny Brewster / ... (3 episodes, 1961-1965) |
| Peter Oliphant | ... | Freddie Helper (3 episodes, 1962-1965) |
| Patty Regan | ... | Arlene Johnson / ... (3 episodes, 1962-1965) |
| Herb Vigran | ... | Alfred Reinbeck / ... (3 episodes, 1962-1965) |
| Cornell Chulay | ... | Candy / ... (3 episodes, 1962-1964) |
| Ken Lynch | ... | Lt. Yarnell / ... (3 episodes, 1962-1964) |
| Valerie Yerke | ... | Cynthia Harding / ... (3 episodes, 1962-1964) |
| Joan Shawlee | ... | Pickles Sorrell (3 episodes, 1963) |
| Bernard Fox | ... | Detective / ... (3 episodes, 1964-1965) |
| Peter Hobbs | ... | Bill Sampson / ... (3 episodes, 1964-1965) |
| Jackie Joseph | ... | Alberta Schweitzer / ... (3 episodes, 1964-1965) |
| Bert Remsen | ... | Announcer / ... (3 episodes, 1965-1966) |
| George Tyne | ... | Doug / ... (3 episodes, 1965-1966) |
| Barbara Dodd | ... | Customer / ... (3 episodes, 1965) |
| Jon Silo | ... | Barber / ... (2 episodes, 1961-1963) |
| Marty Ingels | ... | Sol Pomeroy (2 episodes, 1961-1962) |
| Peter Leeds | ... | Officer Jack Bain / ... (2 episodes, 1961-1962) |
| Barbara Perry | ... | Pickles Sorrell (2 episodes, 1961-1962) |
| Leah Waggner | ... | Martha Goodheart / ... (2 episodes, 1962-1966) |
| Shirley Mitchell | ... | Beth Gregory / ... (2 episodes, 1962-1964) |
| J. Pat O'Malley | ... | Sam Petrie (2 episodes, 1962-1964) |
| Carl Benton Reid | ... | Mr. Meehan (2 episodes, 1962-1964) |
| Charles Aidman | ... | Ed Rubin / ... (2 episodes, 1962-1963) |
| Phil Arnold | ... | Anatole / ... (2 episodes, 1962-1963) |
| Roy Roberts | ... | Henry Bermont / ... (2 episodes, 1962) |
| Elvia Allman | ... | Luthuella / ... (2 episodes, 1963-1965) |
| Madge Blake | ... | Lady / ... (2 episodes, 1963-1965) |
| Greg Morris | ... | Frank Mandalay / ... (2 episodes, 1963-1965) |
| Eddie Ryder | ... | Bert Steele / ... (2 episodes, 1963-1965) |
| Alan Dexter | ... | Hoodlum / ... (2 episodes, 1963) |
| Betty Lou Gerson | ... | Hostess / ... (2 episodes, 1963) |
| Sheldon Leonard | ... | Floyd B. Bariscale / ... (2 episodes, 1963) |
| Tom Tully | ... | Sam Petrie (2 episodes, 1964-1966) |
| Ross Elliott | ... | Dr. Phil Ridley / ... (2 episodes, 1964-1965) |
| Kathleen Freeman | ... | Maid / ... (2 episodes, 1964-1965) |
| Ed McCready | ... | Cameraman / ... (2 episodes, 1964-1965) |
| Jimmy Murphy | ... | Ernie / ... (2 episodes, 1964-1965) |
| Henry Scott | ... | Joe Clark / ... (2 episodes, 1964-1965) |
| Herkie Styles | ... | Benny Joey / ... (2 episodes, 1964-1965) |
| Ken Berry | ... | Tony Daniels (2 episodes, 1964) |
| Sally Carter-Ihnat | ... | Florence / ... (2 episodes, 1964) |
| Don Rickles | ... | Lyle Delp / ... (2 episodes, 1964) |
| Joby Baker | ... | Fred Stagg / ... (2 episodes, 1965-1966) |
| Peter Brocco | ... | Emil / ... (2 episodes, 1965-1966) |
| Bella Bruck | ... | Chambermaid / ... (2 episodes, 1965-1966) |
| John C. Chulay | ... | Cameraman / ... (2 episodes, 1965-1966) |
| Milton Frome | ... | Mr. Evans / ... (2 episodes, 1965-1966) |
| Lee Krieger | ... | Bartender / ... (2 episodes, 1965-1966) |
| Forrest Lewis | ... | Mac / ... (2 episodes, 1965-1966) |
| Garry Marshall | ... | Bartender / ... (2 episodes, 1965-1966) |
| Ed Peck | ... | Captain Worwick / ... (2 episodes, 1965-1966) |
| Michael Conrad | ... | Bernie Stern / ... (2 episodes, 1965) |
| Joel Fluellen | ... | Bailiff / ... (2 episodes, 1965) |
| Alvy Moore | ... | Wiley / ... (2 episodes, 1965) |
