Richard Widmark was apparently very uncomfortable with some of the racist comments his character, Ray Biddle, made, especially given his friendship with Sidney Poitier. As a result, after some of the takes involving particularly venomous remarks, Widmark actually apologized to Poitier for the remarks his character had made.
The poster art was done by Saul Bass. It is his first film credit.
Lesser Samuels' original story was bid on by Warner Brothers, Paramount, Columbia, and Universal-International in addition to Fox, who signed him in January 1949 to a ten week contract to write the screenplay.
Fox contract producers Otto Preminger, Sol Siegel, and Nunnally Johnson all wanted to do the film, but studio head Darryl F. Zanuck produced it personally.
It was the idea of screenplay writer Philip Yordan to depict scenes showing the doctor's family inside their home.
In the original version of the story Luther was hideously slaughtered, but Zanuck changed his mind because he believed that that ending would leave the audience with a "feeling of utter futility."
Although many credit this as Sidney Poitier's film debut, he had previously made three short films for the Signal Corps.
Richard Widmark, who became good friends with Poitier, apologized to the actor on numerous occasions for having to mouth his character's racial epithets.
Zanuck wanted to schedule the release of "No Way Out" a year after "Pinky," a 1949 movie about racial prejudice, because he wanted "a gradual buildup of audience receptivity."
When the black actors who were part of the race riot scene found out that they were getting paid less than their white equivalents, they protested until accommodations were made.
"No Way Out" marks the first screen appearance of Ossie Davis and the first on-screen teaming of Davis and wife Ruby Dee.