 | Pat O'Brien | ... | Knute Rockne |
| Gale Page | ... | Bonnie Skiles Rockne |
| Ronald Reagan | ... | George Gipp |
| Donald Crisp | ... | Father John Callahan, C.S.C |
| Albert Bassermann | ... | Father Julius Nieuwland (as Albert Basserman) |
| John Litel | ... | Committee Chairman |
| Henry O'Neill | ... | Doctor |
| Owen Davis Jr. | ... | Gus Dorais |
| John Qualen | ... | Lars Knutson Rockne |
| Dorothy Tree | ... | Martha Rockne |
| Johnny Sheffield | ... | Knute, Age 7 (as John Sheffield) |
| Moreau Choir of Notre Dame | ... | Themselves |
| Nick Lukats | ... | Four Horseman |
| Kane Richmond | ... | Four Horseman |
| William Marshall | ... | Four Horseman |
| William Byrne | ... | Four Horseman |
| Howard Jones | ... | Himself |
| Glenn 'Pop' Warner | ... | Himself |
| Amos Alonzo Stagg | ... | Himself (as Alonzo Stagg) |
| William 'Bill' Spaulding | ... | Himself |
| rest of cast listed alphabetically: |
| Eddy Chandler | ... | Worker (scenes deleted) |
| Pat Flaherty | ... | Worker (scenes deleted) |
| William Haade | ... | Worker (scenes deleted) |
| Frank Mayo | ... | Reporter (scenes deleted) |
| John Ridgely | ... | Reporter (scenes deleted) |
| Erville Alderson | ... | Kansas Farmer Witnessing Airplane Crash (uncredited) |
| Rudolph Anders | ... | Elder in Norway (uncredited) |
| Peter Ashley | ... | Player (uncredited) |
| Evelyn Atchinson | ... | Bathing Beauty (uncredited) |
| Tommy Baker | ... | Newsboy (uncredited) |
| Tommy Bennett | ... | O'Reilly (uncredited) |
| Georgie Billings | ... | Boy Quarterback (uncredited) |
| Wade Boteler | ... | Trainer (uncredited) |
| Egon Brecher | ... | Elder in Norway (uncredited) |
| David Bruce | ... | Reporter When Knute is Ill (uncredited) |
| Cliff Clark | ... | Danny, Post Office Paymaster (uncredited) |
| Richard Clayton | ... | O'Flaherty, a Student (uncredited) |
| Frank Coghlan Jr. | ... | Messenger (uncredited) |
| Joe Cunningham | ... | Reporter on Train (uncredited) |
| Donald Curtis | ... | West Point Football Player (uncredited) |
| Billy Dawson | ... | Knute Rockne Jr., Age 12 (uncredited) |
| Edgar Dearing | ... | Doc, Knute's Friend at Kansas City Airport (uncredited) |
| Dudley Dickerson | ... | Train Porter (uncredited) |
| David Dickinson | ... | Bill Rockne, Age 10 (uncredited) |
| Lucile Fairbanks | ... | Telephone Operator (uncredited) |
| James Flavin | ... | Army Assistant Coach (uncredited) |
| Bunky Fleischman | ... | Bill Rockne, Age 5 (uncredited) |
| John Gallaudet | ... | Notre Dame Coach Harper (uncredited) |
| Peter B. Good | ... | Bill 'Billy' Rockne, Age 2 (uncredited) |
| Sol Gorss | ... | Man Wheeling Knute's Wheelchair (uncredited) |
| Jack Grant Jr. | ... | Bill Rockne, Age 14 (uncredited) |
| Billy Gratton | ... | Jackie Rockne, Age 4 (uncredited) |
| Creighton Hale | ... | Callahan's Secretary (uncredited) |
| Harry Harvey Jr. | ... | Boy (uncredited) |
| Michael Harvey | ... | Player (uncredited) |
| Harry Hayden | ... | Committee Member (uncredited) |
| Patricia Hayes | ... | Jeannie Rockne, Age 10 (uncredited) |
| George Haywood | ... | Student (uncredited) |
| Oscar 'Dutch' Hendrian | ... | Assistant Coach Hunk Anderson (uncredited) |
| William Hopper | ... | New York Reporter When Knute is Ill (uncredited) |
| George Irving | ... | Doc, a Notre Dame Professor (uncredited) |
| Danny Jackson | ... | Boy (uncredited) |
| Lois James | ... | Bathing Beauty (uncredited) |
| Dickie Jones | ... | Boy Captain (uncredited) |
| Brian Keith | ... | Student at Train Station (uncredited) |
| Owen King | ... | Western Union Clerk in Kansas City (uncredited) |
| Marilyn Kinsley | ... | Bathing Beauty (uncredited) |
| Lois Lindsay | ... | Bathing Beauty (uncredited) |
| Pete Mehringer | ... | Player (uncredited) |
| Carlyle Moore Jr. | ... | Player Eating Bonnie's Chicken (uncredited) |
| Paul Panzer | ... | Extra at Train Station (uncredited) |
| Steve Pendleton | ... | Player #12 (uncredited) |
| Lee Phelps | ... | Army Coach (uncredited) |
| George Reeves | ... | Distraught Player (uncredited) |
| Sam Rice | ... | Extra at Committee Hearing (uncredited) |
| Ruth Robinson | ... | Molly, Gipp's Mother (uncredited) |
| Jeffrey Sayre | ... | Jeff, Reporter on Train (uncredited) |
| Billy Sheffield | ... | Knute Rockne, age 4 (uncredited) |
| Edwin Stanley | ... | Committee Member (uncredited) |
| Phil Thorpe | ... | Boy Center (uncredited) |
| Ruth Tobey | ... | Isobel (uncredited) |
| Charles Trowbridge | ... | Professor (uncredited) |
| Frederick Vogeding | ... | Elder in Norway (uncredited) |
| David Wade | ... | Knute Rockne, Age 7 (uncredited) |
| Pierre Watkin | ... | Commissioner at Hearing (uncredited) |
| Garry Watson | ... | Boy (uncredited) |
| Charles C. Wilson | ... | Gambler (uncredited) |
| Robert Winkler | ... | Tommy (uncredited) |
| Jack Wise | ... | Football Fan at Game (uncredited) |
| Maris Wrixon | ... | Telephone Operator (uncredited) |
