 | Pat O'Brien | ... | Knute Rockne |
 | Gale Page | ... | Bonnie Skiles Rockne |

| Ronald Reagan | ... | George Gipp |
 | Donald Crisp | ... | Father John Callahan, C.S.C |
 | Albert Bassermann | ... | Father Julius Nieuwland (as Albert Basserman) |
 | John Litel | ... | Committee Chairman |
 | Henry O'Neill | ... | Doctor |
 | Owen Davis Jr. | ... | Gus Dorais |
 | John Qualen | ... | Lars Knutson Rockne |
 | Dorothy Tree | ... | Martha Rockne |
 | Johnny Sheffield | ... | Knute, Age 7 (as John Sheffield) |
 | Moreau Choir of Notre Dame | ... | Themselves |
 | Nick Lukats | ... | Four Horseman |
 | Kane Richmond | ... | Four Horseman |
 | William Marshall | ... | Four Horseman |
 | William Byrne | ... | Four Horseman |
 | Howard Jones | ... | Himself |
 | Glenn 'Pop' Warner | ... | Himself |
 | Amos Alonzo Stagg | ... | Himself (as Alonzo Stagg) |
 | William 'Bill' Spaulding | ... | Himself |
| rest of cast listed alphabetically: |
 | Eddy Chandler | ... | Worker (scenes deleted) |

| Pat Flaherty | ... | Worker (scenes deleted) |
 | William Haade | ... | Worker (scenes deleted) |
 | Frank Mayo | ... | Reporter (scenes deleted) |
 | John Ridgely | ... | Reporter (scenes deleted) |
 | Erville Alderson | ... | Kansas Farmer Witnessing Airplane Crash (uncredited) |
 | Rudolph Anders | ... | Elder in Norway (uncredited) |
 | Peter Ashley | ... | Player (uncredited) |
 | Evelyn Atchinson | ... | Bathing Beauty (uncredited) |
 | Tommy Baker | ... | Newsboy (uncredited) |
 | Tommy Bennett | ... | O'Reilly (uncredited) |
 | Georgie Billings | ... | Boy Quarterback (uncredited) |
 | Wade Boteler | ... | Trainer (uncredited) |
 | Egon Brecher | ... | Elder in Norway (uncredited) |
 | David Bruce | ... | Reporter When Knute is Ill (uncredited) |
 | Cliff Clark | ... | Danny, Post Office Paymaster (uncredited) |
 | Richard Clayton | ... | O'Flaherty, a Student (uncredited) |
 | Frank Coghlan Jr. | ... | Messenger (uncredited) |
 | Joe Cunningham | ... | Reporter on Train (uncredited) |
 | Donald Curtis | ... | West Point Football Player (uncredited) |
 | Billy Dawson | ... | Knute Rockne Jr., Age 12 (uncredited) |
 | Edgar Dearing | ... | Doc, Knute's Friend at Kansas City Airport (uncredited) |
 | Dudley Dickerson | ... | Train Porter (uncredited) |
 | David Dickinson | ... | Bill Rockne, Age 10 (uncredited) |
 | Lucile Fairbanks | ... | Telephone Operator (uncredited) |
 | James Flavin | ... | Army Assistant Coach (uncredited) |
 | Bunky Fleischman | ... | Bill Rockne, Age 5 (uncredited) |
 | John Gallaudet | ... | Notre Dame Coach Harper (uncredited) |
 | Peter B. Good | ... | Bill 'Billy' Rockne, Age 2 (uncredited) |
 | Sol Gorss | ... | Man Wheeling Knute's Wheelchair (uncredited) |
 | Jack Grant Jr. | ... | Bill Rockne, Age 14 (uncredited) |
 | Billy Gratton | ... | Jackie Rockne, Age 4 (uncredited) |
 | Creighton Hale | ... | Callahan's Secretary (uncredited) |
 | Harry Harvey Jr. | ... | Boy (uncredited) |
 | Michael Harvey | ... | Player (uncredited) |
 | Harry Hayden | ... | Committee Member (uncredited) |
 | Patricia Hayes | ... | Jeannie Rockne, Age 10 (uncredited) |
 | George Haywood | ... | Student (uncredited) |
 | Oscar 'Dutch' Hendrian | ... | Assistant Coach Hunk Anderson (uncredited) |
 | William Hopper | ... | New York Reporter When Knute is Ill (uncredited) |

| George Irving | ... | Doc, a Notre Dame Professor (uncredited) |
 | Danny Jackson | ... | Boy (uncredited) |
 | Lois James | ... | Bathing Beauty (uncredited) |
 | Dickie Jones | ... | Boy Captain (uncredited) |
 | Brian Keith | ... | Student at Train Station (uncredited) |
 | Owen King | ... | Western Union Clerk in Kansas City (uncredited) |
 | Marilyn Kinsley | ... | Bathing Beauty (uncredited) |
 | Lois Lindsay | ... | Bathing Beauty (uncredited) |
 | Pete Mehringer | ... | Player (uncredited) |

| Carlyle Moore Jr. | ... | Player Eating Bonnie's Chicken (uncredited) |
 | Paul Panzer | ... | Extra at Train Station (uncredited) |
 | Steve Pendleton | ... | Player #12 (uncredited) |
 | Lee Phelps | ... | Army Coach (uncredited) |

| George Reeves | ... | Distraught Player (uncredited) |
 | Sam Rice | ... | Extra at Committee Hearing (uncredited) |
 | Ruth Robinson | ... | Molly, Gipp's Mother (uncredited) |
 | Jeffrey Sayre | ... | Jeff, Reporter on Train (uncredited) |
 | Billy Sheffield | ... | Knute Rockne, age 4 (uncredited) |
 | Edwin Stanley | ... | Committee Member (uncredited) |
 | Phil Thorpe | ... | Boy Center (uncredited) |
 | Ruth Tobey | ... | Isobel (uncredited) |
 | Charles Trowbridge | ... | Professor (uncredited) |
 | Frederick Vogeding | ... | Elder in Norway (uncredited) |
 | David Wade | ... | Knute Rockne, Age 7 (uncredited) |
 | Pierre Watkin | ... | Commissioner at Hearing (uncredited) |
 | Garry Watson | ... | Boy (uncredited) |
 | Charles C. Wilson | ... | Gambler (uncredited) |
 | Robert Winkler | ... | Tommy (uncredited) |
 | Jack Wise | ... | Football Fan at Game (uncredited) |
 | Maris Wrixon | ... | Telephone Operator (uncredited) |