The nightclub featured in the film was loosely modeled on the famous Forbidden City, a popular San Francisco night spot from the late 1930s through the 1950s.
Though William Powell and Myrna Loy were very close friends off-screen, their only romantic moments together occurred on-screen. The public, however, was determined to have them married in private life as well. When the two stars showed up in San Francisco (where most of After the Thin Man (1936) was shot) at the St. Francis, the hotel management proudly showed "Mr. and Mrs. Powell" to their deluxe suite. This was an especially uncomfortable moment as Jean Harlow, who was engaged to Powell, was with them, and the couple had not made a public statement about their relationship. Harlow saved the day by insisting on sharing the suite with Loy: "That mix-up brought me one of my most cherished friendships," Loy said in her biography Being and Becoming. "You would have thought Jean and I were in boarding school we had so much fun. We'd stay up half the night talking and sipping gin, sometimes laughing, sometimes discussing more serious things." Meanwhile, Powell got the hotel's one remaining room - a far humbler accommodation downstairs.