Boris Karloff had been the studio's original choice for the role of the Invisible Man. He turned down the role because he would not be seen on screen until the end. Director
James Whale wanted someone with more of an "intellectual" voice than Karloff. He selected
Claude Rains after accidentally hearing Rains's screen test being played in another room. (Until this film, Rains had primarily been a stage actor. Although he had appeared in one silent movie in 1920, this was his first sound film.)
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