
| Will Rogers | ... | Dr. George 'Doc' Bull |
 | Vera Allen | ... | Mrs. Janet 'Jane' Cardmaker, Widow of Charles Edward Cardmaker / Bull's Girlfriend |
 | Marian Nixon | ... | May Tupping - Telephone Operator |
 | Howard Lally | ... | Joe Tupping |
 | Berton Churchill | ... | Herbert Banning - Janet's Brother |
 | Louise Dresser | ... | Mrs. Herbert Banning |
 | Andy Devine | ... | Larry Ward, Sodajerk |
 | Rochelle Hudson | ... | Virginia (Muller) / Banning |
 | Tempe Pigott | ... | Grandma Banning |
 | Elizabeth Patterson | ... | Aunt Patricia Banning |
 | Nora Cecil | ... | Aunt Emily Banning |
 | Ralph Morgan | ... | Dr. Verney, Owner Verney Laboratory |
 | Patsy O'Byrne | ... | Susan - Dr. Bull's Cook |
 | Veda Buckland | ... | Mary - Janet's Maid |
 | Effie Ellsler | ... | Aunt Myra Bull |
 | Helen Freeman | ... | Helen Upjohn, New Winton Postmistress |
| rest of cast listed alphabetically: |
 | Reginald Barlow | ... | Supporter #1 for Dr. Bull (uncredited) |
 | Louise Carter | ... | Mrs. Ely, New Winton's Gossip (uncredited) |
 | James Donlan | ... | Harry Weems - Supporter #3 for Dr. Bull (uncredited) |
 | Mike Donlin | ... | Lester Dunn - Supporter #2 for Dr. Bull (uncredited) |
 | Francis Ford | ... | Mr. Herring, Metting Chairman (uncredited) |
 | Ethel Griffies | ... | Miss Ace (uncredited) |
 | Otis Harlan | ... | Agitator (uncredited) |
 | George Humbert | ... | Louis Papolita, New Father of Boy (uncredited) |
 | Si Jenks | ... | Gaylord, Janet's Farmhand (uncredited) |
 | Cammilla Johnson | ... | Little Girl (uncredited) |
 | Marcia Mae Jones | ... | Ruth, a School Girl (uncredited) |
 | Charles Middleton | ... | Mr. Upjohn, Selectman (uncredited) |
 | Sarah Padden | ... | Mary the Canning Cook (uncredited) |
 | Robert Parrish | ... | Teenager (uncredited) |
 | Billy Watson | ... | Billy Watson, School Boy (uncredited) |