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Top grossing movies for 2006 in the USA
Please note that these are the top grossing films that were first released in 2006; because they may have made most of their income in a later year, they are probably not the top grossing films for calendar year 2006.
| Gross | | Movie |
| 423,032,628 | | Pirates of the Caribbean: Dead Man's Chest (2006) |
| 250,863,268 | | Night at the Museum (2006) |
| 244,052,771 | | Cars (2006) |
| 234,360,014 | | X-Men: The Last Stand (2006) |
| 217,536,138 | | The Da Vinci Code (2006) |
| 210,592,590 | | 300 (2006) |
| 200,069,408 | | Superman Returns (2006) |
| 197,992,827 | | Happy Feet (2006) |
| 195,329,763 | | Ice Age: The Meltdown (2006) |
| 167,445,960 | | Casino Royale (2006) |
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